Migraine is the most common vascular headache. It is often one-sided pain, sometimes accompanied by nausea, vomiting, phonophobia, photophobia, etc. The pathogenesis of migraine is complex and has not yet been fully elucidated. There are neurological signs and symptoms during the aura stage when cerebral blood flow decreases sharply. Typical migraine headaches are often caused by localized congestion, following the reduction in ductile blood flow, the blood flow in the brain and extracranial blood vessels increases, the vascular pulse amplitude increases, and the increase in intracranial arteries is more obvious. In addition, metabolic disorders such as prostaglandins, neurokinins, acetylcholine, and histamine, as well as endocrine dysfunction, are also related to the onset of migraine, particularly 5-HT metabolism. Commonly used drugs in clinical practice are 5-HT antagonists, antihistamines, calcium antagonists, and adrenoceptor blocking drugs, etc.

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