Preservatives Excipients


Preservatives, sometimes called bacteriostats, are chemicals that inhibit the growth of microorganisms. The same substance exhibits a bacteriostatic effect at low concentrations and a bactericidal effect at higher concentrations. Many disinfecting and antiseptic drugs are often good preservatives in formulations.

Mechanism of Preservatives

1. Denaturing, precipitating, or coagulating the protein of pathogenic microorganisms, such as ethanol, benzyl alcohol, etc.

2. Combine with the enzyme system of pathogenic microorganisms, affect, or block its metabolic process, such as benzoic acid and hydroxybenzene esters, acting on the cell membrane of bacteria or competing for their coenzymes.

3. Reduce the surface tension, increase the permeability of the plasma membrane of the bacterial body, make the cell rupture, lysis, such as some cationic surfactants

Subtypes of Preservative Excipients


Parabens, including methylparaben, ethylparaben, and propylparaben, are widely used as preservatives due to their antimicrobial properties. They exhibit a broad spectrum of activity against various microorganisms and are commonly used in liquid oral formulations, topical creams, and ophthalmic solutions.

Benzalkonium Chloride

Benzalkonium chloride is a quaternary ammonium compound that acts as a potent antimicrobial agent. It is effective against a wide range of pathogens and is commonly utilized in nasal sprays, eye drops, and ophthalmic ointments.

Benzyl Alcohol

Benzyl alcohol is widely used as a preservative in parenteral formulations, such as injectable solutions and multi-dose vials. It demonstrates antimicrobial activity against bacteria and fungi and is well-tolerated by most patients.


Phenol is an antiseptic and preservative that exhibits both bactericidal and fungicidal properties. It is used in a variety of pharmaceutical products, including throat sprays, topical creams, and dermatological preparations.



Methylparaben is a commonly employed paraben preservative excipient. It is widely used in oral liquids, creams, and lotions. Methylparaben offers excellent antimicrobial activity and is well-tolerated by patients.


Chlorobutanol is another effective preservative that demonstrates broad-spectrum antimicrobial activity. It is commonly used in injectable solutions, eye drops, and nasal preparations.


Thimerosal, a mercury-containing compound, is utilized as a preservative in vaccines, preventing bacterial and fungal contamination. It ensures the stability and sterility of the vaccine formulations.


Preservative excipients are crucial in maintaining patient safety and product integrity. They prevent the growth of microorganisms that may compromise the efficacy of pharmaceutical products and pose risks to patient health. Without proper preservation, products may become contaminated, reducing their shelf life and potentially causing adverse effects. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0060 Povidone iodine 25655-41-8 View Details APIs
PIE-0065 Chlorobutanol Hemihydrate 6001-64-5 View Details APIs
PIE-0080 Benzalkonium Chloride 8001-54-5 View Details APIs
PIE-0085 Pentetic Acid 67-43-6 View Details APIs
PIE-0086 Thymol 89-83-8 View Details APIs
PIE-0087 Methylparaben 99-76-3 View Details APIs
PIE-0088 Propylparaben 94-13-3 View Details APIs
PIE-0092 Benzyl Alcohol 100-51-6 View Details APIs
PIE-0093 Sodium Methylparaben 5026-62-0 View Details APIs
PIE-0094 Sodium Ethylparaben 35285-68-8 View Details APIs
PIE-0095 Sodium Propylparaben 35285-69-9 View Details APIs
PIE-0108 potassium metabisulfite 16731-55-8 View Details APIs
PIE-0115 Camphor 76-22-2 View Details APIs
PIE-0117 Potassium Sorbate 24634-61-5 View Details APIs
PIE-0118 Sorbic acid 110-44-1 View Details APIs
PIE-0121 Sodium Benzoate 532-32-1 View Details APIs
PIE-0125 Tannic Acid 1401-55-4 View Details APIs
PIE-0134 2,3,4-Trihydroxybenzaldehyde 218-404-2 View Details APIs
PIE-0135 Ellagic acid 476-66-4 View Details APIs
PIE-0137 Benzoic acid 65-85-0 View Details APIs


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