Diluent Excipients


Diluent excipients serve multiple purposes in solid dosage forms, including filling and Bulking, tablet compression, dosage uniformity.

Subtypes of Diluent Excipients

Inorganic Diluents

Inorganic diluents include substances such as microcrystalline cellulose (MCC), dibasic calcium phosphate, and lactose. These diluents offer excellent compressibility, flowability, and stability for solid dosage forms. For example, MCC is widely used due to its favorable physical properties, low moisture content, and compatibility with a wide range of drug substances.

Organic Diluents

Organic diluents encompass materials such as starch (corn, potato, or modified starches), mannitol, and sorbitol. These excipients provide desirable properties such as good compactibility, rapid disintegration, and sweetness when used in orally disintegrating tablets (ODTs). Organic diluents are also suitable for moisture-sensitive APIs.

Co-Processed Diluents

Co-processed diluents are blends of two or more excipients designed to combine their individual benefits and address specific formulation challenges. Examples include co-processed mixtures of lactose and MCC, which offer improved compressibility, flowability, and tablet disintegration properties.



Diluent excipients find extensive use in tablet formulations, where they act as bulking agents to achieve the desired tablet weight and promote uniformity. Depending on the specific requirements of the formulation, different diluents can be selected to optimize tablet hardness, friability, and disintegration time.


In capsule formulations, diluent excipients are utilized to fill the empty space in the capsule shell, ensuring proper dosage and content uniformity. Diluents with excellent flow properties and compatibility with active ingredients are preferred to enhance the encapsulation process.

Granules and Pellets

Diluent excipients are essential in the preparation of granules or pellets for controlled-release formulations. By providing volume and uniformity to the granulation process, they contribute to effective drug release profiles and content uniformity.


For dry powder formulations, diluents are used to achieve proper mixing, flowability, and dosage accuracy. In inhalation powders, for instance, diluents help ensure proper dispersion and delivery of the active ingredient to the respiratory system.


Diluent excipients are vital components in the development of pharmaceutical dosage forms, providing the necessary volume, weight, and formulation properties for solid formulations. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.



Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

  • Tel:
  • E-mail:
  • Address:
  • WhatsAPP
Privacy Policy | Cookie Policy
Copyright © Protheragen-ING. All Rights Reserved.
Member of