Spray Drying Formulations Development

As a leading provider of pharmaceutical formulation solutions, Protheragen-ING offers spray drying formulation development services dedicated to helping customers overcome the challenges associated with difficult-to-solve aqueous molecules and difficult-to-formulate drugs. With our expertise in spray drying technology, we offer tailored formulation development services to help you achieve optimal drug solubility and bioavailability.

What is SDD?

Spray drying is a technique widely used in the pharmaceutical industry to convert liquid formulations into dry powders. It involves atomizing a liquid feed solution into a fine mist and drying it rapidly by applying hot air. The result is a dry powder with enhanced stability, improved processability, and increased surface area.

Spray-dried dispersion (SDD) refers to a specific type of formulation produced by spray drying in which the active pharmaceutical ingredient (API) is dispersed in a polymeric matrix or carrier material. SDDs are commonly used to enhance the solubility and dissolution rate of difficult-to-solubilize drugs, resulting in improved bioavailability and therapeutic efficacy.

Fig.1 The spray-drying technique.Fig. 1 The spray-drying technique. (Sosnik A, et al. 2015)

Protheragen-ING's SSD Development Services

Our team specializes in the development of spray-dried formulations of difficult-to-solve water molecules and difficult-to-formulate drugs. We combine our scientific expertise, state-of-the-art facilities, and advanced technologies to create innovative solutions that optimize drug solubility and bioavailability. Our SDD drug platform supports a wide range of dosage forms, including tablets, capsules, powders, and granules.

Our comprehensive services include:

Formulation design Our experienced scientists work closely with you to understand your drug development goals and develop a customized spray drying solution. We design optimized formulations that take into account factors such as API characteristics, target product profile, and patient needs.
Process optimization We use advanced spray drying technologies and process parameters to achieve the desired particle size, morphology, and drug-polymer interactions. Through meticulous process optimization, we ensure that the formulations developed are reproducible, scalable and manufacturable.
Analytical characterization We utilize a range of analytical techniques to evaluate the physical and chemical properties of spray-dried formulations. This includes particle size analysis, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and solubility testing to assess the solubility and stability of formulated products.
Scale-up and manufacturing support Our state-of-the-art equipment and facilities enable seamless spray drying development and manufacturing from lab scale to clinical and commercial stages.

Experienced with all SDD polymers and solvents

Advantages of Spray-Dried Formulations

Fig.2 Spray Drying Formulations Development.

Contact us today to discuss your specific requirements and how we can help you achieve formulation success.


  1. Sosnik A, et al. (2015). "Advantages and Challenges of The Spray-drying Technology for The Production of Pure Drug Particles and Drug-loaded Polymeric Carriers." Advances in Colloid and Interface Science, 223, 40-54.


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