Ointment Development Services


Ointments are semi-solid preparations, usually for topical application to the skin or mucous membranes. They are often used for their soothing, protective, or medicinal properties. Ointments are made by mixing a medicinal substance with a base or carrier, which is usually an oily or semi-solid material that helps deliver the drug to the affected area. They provide a convenient and effective way to administer medications for the treatment of various skin conditions, pain relief, wound healing, and more.

Protheragen-ING offers comprehensive ointment development services to provide full support in customizing formulations, testing, and manufacturing according to your specific needs. We have the expertise, facilities, and quality systems to guide you through every stage of the pharmaceutical ointment development process. Our team of experienced professionals will work closely with you to develop customized ointment formulations that meet regulatory requirements and provide optimal therapeutic benefits.

Classification of Ointment Formulations

Ointment Preparation Methods

We mix an active pharmaceutical ingredient (API) with a suitable matrix or carrier to form a semi-solid ointment preparation. Preparation methods can vary depending on the specific requirements of the ointment. Some common methods include:

Formulation of Ointment Bases

Oleaginous Base (White Ointment) White Wax 5%
White Petrolatum 95%
Absorption Base Cholesterol 3%
Stearyl Alcohol 3%
White Wax 8%
White Petrolatum 86%
O/W Emulsion Base (Hydrophilic Ointment) Sodium Lauryl Sulfate 1%
Propylene Glycol 12%
Stearyl Alcohol 25%
White Petrolatum 25%
Purified Water 37%
W/O Emulsion Base (Cold Cream type base) White wax 12.00%
Cetyl Esters Wax (or Spermaceti) 12.50%
Mineral Oil 56.00%
Sodium Borate 0.50%
Water 19.00%
Water Soluble Base Polyethylene Glycol 400 60%
Polyethylene Glycol 3350 40%

The manufacturing process of the ointment

1. Preparation of oil phase.

Components for tablets or powders are pre-dry-mixed and distributed into mineral or silicone oils. Some ingredients may need to be heated in order to melt.

2. Hydration of aqueous phase ingredients.

Separate containers are used to disperse stabilizers, thickeners, and emulsifiers in water. It could take heat to speed up the hydration process.

3. Emulsion Formation.

Creating an emulsion by thoroughly agitating and mixing the two stages.

4. Dispersion of Active Ingredients.

Usually comprising only a tiny percentage of a formulation, active Ingredients need to be dispersed efficiently to optimize yield and product efficiency.

Schematic diagram of the SHRO cream delivery system depicting the formulation, application and activation of the product.Fig. 1 Schematic diagram of the SHRO cream delivery system depicting the formulation, application and activation of the product. (O'Farrell C, et al. 2022)

Please contact us to learn more about our ointment development service and how we can assist you in bringing your innovative ointment formulations to market.


  1. O'Farrell C, et al. (2022). "Formulation of An Antibacterial Topical Cream Containing Bioengineered Honey That Generates Reactive Oxygen Species." Biomaterials Advances, 133, 112664.


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