Disintegrant Excipients

Pharmaceutical disintegrant excipients are substances added to solid dosage forms to facilitate their rapid breakup or disintegration when in contact with an aqueous medium, such as gastrointestinal fluids. These excipients promote the dispersion of the active pharmaceutical ingredient (API) and other formulation components, leading to enhanced dissolution and bioavailability. Protheragen-ING offers disintegrant excipients. Protheragen-ING has pharmaceutical experts, laboratory employees, and professional lab equipment, in order to guarantee product purity and performance to fulfill your needs. Along with providing products, we also offer customized disintegrant excipients and product solutions to assist you in R&D process.

Classification of Disintegrant Excipients

Various types of disintegrant excipients are available, each with distinct properties that determine their effectiveness in specific formulations. The most commonly used disintegrants include:

  1. Starches: Starch-based disintegrants such as microcrystalline cellulose (MCC), sodium starch glycolate (SSG), and pre-gelatinized starch are widely utilized in tablet formulations. These excipients rapidly absorb water, causing swelling and subsequent tablet disintegration.
  2. Modified Cellulosics: Cellulosic-based disintegrants like croscarmellose sodium (CCS), crospovidone (CP), and sodium carboxymethylcellulose (CMC) are highly effective in promoting disintegration. They create a porous matrix upon hydration, allowing the rapid release of drug particles.
  3. Ion Exchange Resins: These disintegrants work by exchanging ions with their surroundings upon contact with aqueous fluids. Examples include crosslinked polyvinylpyrrolidone (PVPP) and crosslinked polyvinylpolypyrrolidone (PVPP-P).
  4. Alginates: Sodium alginate and calcium alginate are natural polysaccharides derived from seaweed. These disintegrants undergo rapid swelling and gel formation upon hydration, facilitating tablet breakdown.

Applications of Disintegrant Excipients

The choice of disintegrant excipient depends on factors such as the drug's physicochemical properties, desired dissolution profile, manufacturing process requirements, and patient acceptability. Pharmaceutical manufacturers often tailor the disintegrant formulation to optimize the desired release rate, dosage form integrity, and patient experience. Some key applications include:

Immediate-Release Formulations

Disintegrant excipients are crucial in immediate-release formulations, where rapid disintegration and dissolution are desired for quick drug release and absorption.

Orally Disintegrating Tablets (ODTs)

Disintegrant excipients are essential in ODTs, which are designed to disintegrate rapidly in the mouth without the need for water. This allows for convenient administration, especially for patients who have difficulty swallowing conventional tablets.

Fast-Dissolving Tablets

Disintegrant excipients are employed in fast-dissolving tablets, which are designed to dissolve quickly in the mouth, allowing for rapid drug release and absorption.

Disintegrant excipients are essential components of solid dosage formulations, enabling fast disintegration, enhanced drug release, and improved therapeutic outcomes. With a diverse range of disintegrant excipients available, pharmaceutical companies can select the most suitable option based on their formulations' specific requirements. The proper utilization of these excipients facilitates patient adherence and ensures the efficient delivery of pharmaceutical products. Protheragen-ING is a leading pharmaceutical products supplier, assisting the pharmaceutical industry to improve the performance of the final products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0028 Microcrystalline Cellulose 9004-34-6 View Details APIs
PIE-0029 Croscarmellose Sodium 74811-65-7 View Details APIs
PIE-0031 N-Vinyl-2-pyrrolidone, PVPP 9003-39-8 View Details APIs
PIE-0032 PVP-K30 9003-39-8 View Details APIs
PIE-0033 Sodium carboxyl methylstarch, CMS-Na 9063-38-1 View Details APIs
PIE-0034 Wheat Starch 9005-25-8 View Details
PIE-0035 Pregelatinized Starch 9005-25-8 View Details
PIE-0040 Low-Substituted Hydroxypropyl cellulose 9004-64-2 View Details APIs
PIE-0044 Silicone Dioxide 61790-53-2 View Details
PIE-0046 Potato Starch 68412-29-3 View Details
PIE-0047 Maize Starch 65996-63-6 View Details
PIE-0051 Co-Processed Microcrystalline Cellulose and Colloidal Silicon Dioxide / View Details
PIE-0052 Carboxymethylcellulose Calcium 9050-04-8 View Details APIs
PIE-0053 Lactose 14641-93-1 View Details APIs
PIE-0055 Sodium Stearyl Fumarate 4070-80-8 View Details APIs
PIE-0110 Glycine 56-40-6 View Details APIs
PIE-0119 Citric acid 77-92-9 View Details APIs
PIE-0306 Sodium Carbonate Monohydrate 5968-11-6 View Details APIs
PIE-0361 XL View Details
PIE-0362 XL-10 View Details


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