Filler Excipients


Filler is used to increase the weight and volume of drugs or disperse raw materials to lessen the material's viscosity to make it easier to prepare molding and dosage of excipients, or for the absorption of raw materials in a lot of liquid ingredients in the excipient, which can be divided into two categories of diluent or absorbent. It is frequently employed in formulations that are solid, like tablets, granules, capsules, and dispersions.

Subtypes of Filler Excipients

Microcrystalline Cellulose (MCC)

MCC is one of the most widely used filler excipients in pharmaceutical formulations. It is derived from cellulose and offers excellent compressibility, bulking properties, and stability. MCC is commonly used in tablet formulations due to its flowability and compatibility with various active ingredients.


Lactose, a sugar derived from milk, is another common filler excipient. It is highly versatile and provides good compressibility and flowability. Lactose is often used in orally disintegrating tablets, as it aids in the rapid disintegration of the dosage form.


Various types of starches, such as corn starch and pregelatinized starch, serve as filler excipients. Starches offer good binding and disintegration properties and are commonly used in tablet and capsule formulations.

Calcium Phosphates

Calcium phosphates, including dibasic calcium phosphate and tricalcium phosphate, are frequently used as filler excipients. These substances provide excellent compressibility, flowability, and tablet hardness.


Tablet Formulations

Filler excipients are extensively used in tablet formulations to achieve the desired tablet size and shape, enhance stability, and facilitate proper dosage administration. MCC, lactose, starches, and calcium phosphates are commonly used in tablet manufacturing.

Capsule Formulations

In capsule formulations, filler excipients are used to provide bulk and ensure uniformity. MCC, lactose, and starches are commonly employed in capsule filling processes.

Direct Compression

Filler excipients are crucial in direct compression manufacturing methods. They enhance flowability and compressibility, making it easier to produce tablets without the need for granulation.

Oral Disintegrating Tablets

Filler excipients such as lactose and specialty disintegrants are essential components in orally disintegrating tablets. These excipients aid in rapid disintegration, allowing for easy administration and enhanced patient compliance.

Significance of Filler Excipients

Dosage Form Accuracy: Filler excipients help ensure accurate dosing and uniformity in pharmaceutical formulations, improving patient adherence to prescribed treatments.

Manufacturing Efficiency: Optimal flowability and compressibility provided by filler excipients contribute to streamlined manufacturing processes, reducing production costs and enhancing productivity.

Drug Stability: Filler excipients play a vital role in protecting active ingredients from degradation, enhancing shelf life, and maintaining the efficacy of pharmaceutical products.

Patient Experience: Properly chosen filler excipients contribute to the overall quality of pharmaceutical formulations, facilitating ease of administration and enhancing patient experience.


Filler excipients are essential components in pharmaceutical formulations, enabling efficient manufacturing, enhancing stability, and improving patient compliance. From bulking agents to disintegrants, these substances contribute significantly to the quality and efficacy of pharmaceutical products. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0006 Sucrose (for injection) 57-50-1 View Details APIs
PIE-0031 N-Vinyl-2-pyrrolidone, PVPP 9003-39-8 View Details APIs
PIE-0032 PVP-K30 9003-39-8 View Details APIs
PIE-0034 Wheat Starch 9005-25-8 View Details
PIE-0035 Pregelatinized Starch 9005-25-8 View Details
PIE-0047 Maize Starch 65996-63-6 View Details
PIE-0048 Dextrin 9004-53-9 View Details APIs
PIE-0056 Calcium Hydrogen Phosphate Anhydrous 7757-93-9 View Details APIs
PIE-0057 Calcium Hydrogen Phosphate Dihydrate 7789-77-7 View Details APIs
PIE-0111 Sodium chloride 7647-14-5 View Details APIs
PIE-0124 D-Mannitol 69-65-8 View Details APIs


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