Protein-based Nanoparticles Development Services

Recently, biopolymer-based nanoparticles, such as protein-based nanoparticles (PNPs), have been actively used as drug and functional tools due to their low toxicity and biodegradability. Protheragen-ING specializes in the creation of innovative and effective drug delivery systems (DDSs) using PNPs.

We offer a range of services tailored to meet the unique needs of pharmaceutical companies, researchers, and healthcare professionals. Whether you are looking to enhance drug efficacy, improve bioavailability, or explore targeted delivery options, we can provide you with superior solutions in the field of nanoparticle development.

Protein-based Nanoparticles

Proteins exhibit unique functions and properties in the field of biomaterials and manufacturing that can be used as base materials for nanoparticle production. PNPs utilize the unique properties of proteins to deliver therapeutic agents to specific targets in the body. These nanoparticles are designed to encapsulate drugs, peptides, or nucleic acids, providing protection and controlled release mechanisms. Due to their small size, PNPs can be propagated through cells by cytosis.

Fig.1 The three phases of PNP delivery and the pathophysiological barriers they encounter after systemic administration.Fig. 1 The three phases of PNP delivery and the pathophysiological barriers they encounter after systemic administration (i.e., intravenous injection). (Sandra F, et al. 2019)

PNPs as DDSs offer several advantages, such as biodegradability, stability, particle surface modification, ease of particle size control, and fewer problems associated with toxicity issues, such as immunogenicity. In particular, the stability, activity, and half-life of the drug can be improved by protecting it from enzymatic degradation and renal clearance.

Our Services

Protheragen-ING offers a full range of services to support your drug delivery needs. Our services include:

As DDSs, the main objective of designing nanoparticles is to control the particle size, surface area, and surface properties so that the nanoparticles carrying the necessary amount of drug exhibit the desired pharmacological activity by releasing the active agent for site-specific action.

We specialize in the design and engineering of PNPs customized to your specific requirements. Our team of experts utilizes advanced computational and experimental techniques to create nanoparticles with optimal drug delivery properties.

We provide formulation development services to optimize the encapsulation and release characteristics of therapeutics. Our formulation experts work closely with you to ensure drug stability, bioavailability, and controlled release.

We assist in developing targeting strategies by binding ligands or antibodies to the surface of PNPs. This enables precise targeting of specific cells, tissues, or organs, increasing therapeutic efficacy and minimizing side effects.

We offer comprehensive characterization and analysis services to assess the physicochemical properties, stability, and release kinetics of PNPs. Our advanced analytical techniques ensure accurate and reliable data for informed decision makingdecision-making.

We support the scale-up and manufacturing of PNPs for preclinical and clinical studies. Our manufacturing capabilities follow stringent quality standards to ensure reproducible and scalable nanoparticle production.

Our Methods for Preparing PNPs

Fig.2 Categorization of methods for preparing PNPs.Fig. 2 Categorization of methods for preparing PNPs. (Hone S, et al. 2021)

Engineering Strategies for Maximizing PNP Delivery in Vivo

Purpose Engineering Strategy
Prolong circulation half-life PEGylation
Albumin coating
CD47 "self-peptide"
Blood-circulating peptide-1 (BCP-1)
Increase tumor accumulation Tumor vasculature disruption (PDT)
Elongated PNPs
Improve tumor penetration and diffusion Receptor-mediated transcytosis
Elongated/High aspect ratio
ECM degradation (via PDT)
Enhance cellular uptake Cell-targeting peptide (with PEG spacer)
Cleavable-stealth coating
Mediate endo/lysosomal escape Cell-penetrating peptide
Fusogenic peptide

Contact us today to learn more about our services and how we can assist you in harnessing the potential of protein-based nanoparticles for advanced drug delivery.


  1. Sandra F, et al. (2019). "Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging." Nanomaterials (Basel), 9(9), 1329.
  2. Hone S, et al. (2020). "Protein-Based Nanoparticles as Drug Delivery Systems." Pharmaceutics, 12(7), 604.


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