Headspace Gas Analysis for Pharmaceutical Packaging

In the pharmaceutical industry, the quality of packaging plays a vital role in the protection and stability of pharmaceuticals. Headspace analysis technology is a method widely used in pharmaceutical packaging quality control to evaluate the content of gases such as oxygen and carbon dioxide inside pharmaceutical packaging. This technology can monitor the gas environment inside drug packaging in real time and accurately, thereby evaluating the barrier performance of the packaging and the storage status of the drug, and providing key information for the quality and stability of the drug.

Protheragen-ING understands the critical importance of ensuring the quality and integrity of pharmaceutical products throughout their life cycle. Our advanced headspace gas analysis solutions provide accurate and reliable data, allowing you to maintain the highest safety and effectiveness standards for pharmaceutical packaging.

Customized Analysis Services

Protheragen-ING provides comprehensive headspace gas analysis services designed to meet the pharmaceutical industry's quality control needs for pharmaceutical packaging. Utilizing state-of-the-art equipment and industry-recognized methodologies, our expert team can provide customized analytical solutions based on your specific requirements.

We use a variety of analytical methods to evaluate headspace gases in pharmaceutical packaging, including gas chromatography-mass spectrometry (GC-MS), gas chromatography-flame ionization detector (GC-FID), and gas chromatography-thermal conductivity detector (GC-TCD), etc. These methods can effectively separate and quantify gas components in the headspace, including volatile organic compounds (VOCs), moisture content, oxygen content, carbon dioxide content, and other possible impurities.

To ensure the accuracy and reliability of analysis, we are equipped with advanced analytical instruments and equipment. These instruments provide high sensitivity, high resolution, and reliable performance to accurately detect and quantify trace gas components in the head space.

Professional Analysis Technology

Our technical team is skilled in a variety of analytical techniques to accurately extract and analyze headspace gases, including:

• Static headspace analysis
• Dynamic headspace analysis.
• Purge and trap.
• Solid phase microextraction (SPME).

Based on the characteristics and requirements of pharmaceutical packaging, we can select appropriate technologies to effectively capture and analyze headspace gas and provide reliable results and interpretations.

Fig. 1 The laboratory set up of headspace gas analysis. (Rovira D, et al. 2019)

Applications of Our Analytics Services

• Leak Detection - This analysis helps detect changes in headspace gas composition, such as increased oxygen levels or the presence of environmental contaminants, indicating potential leaks.
• Contamination Monitoring - This analysis can identify the presence of such contaminants, providing early warning signs of potential issues that may affect product stability, efficacy, or safety.
• Stability Assessment - By monitoring headspace gas over time, product stability can be assessed, and informed decisions can be made regarding packaging design or shelf life.
• Packaging Integrity Assessment - This analysis can identify issues affecting product quality, such as incorrect sealing, improper closure, or improper packaging materials. By evaluating headspace gas, deviations from expected composition can indicate potential issues with package integrity.
• Quality Control - By analyzing headspace gases, pharmaceutical manufacturers can ensure that their packaging systems comply with required standards and regulatory guidelines.

By partnering with us, you gain access to reliable analytical data, regulatory compliance, and the peace of mind that comes from knowing your packaging systems meet the highest industry standards. Contact us today to discuss your specific requirements and how we can support your pharmaceutical packaging analysis needs.