Sustained Release Tablets

Sustained release tablets are oral dosage forms designed to provide a gradual and sustained release of an active pharmaceutical ingredient (API) over an extended time. Unlike immediate-release tablets, which deliver the drug quickly into the bloodstream, sustained release tablets provide a controlled and sustained release of the drug, thereby maintaining therapeutic drug levels in the body for a longer period.

Protheragen-ING specializes in the development and manufacture of high-quality sustained release tablets. With our expertise in drug formulation and advanced manufacturing technologies, we offer a full range of services to take your sustained release tablet formulation from concept to market.

Benefits of Sustained Release Tablets

Fig.1 Sustained Release Tablets

Types of Sustained Release Tablets

Protheragen-ING can develop the following types of sustained release tablets:

Matrix Controlled-Release Tablets The drug in this sustained release tablet is uniformly dispersed in a porous matrix, which may be water-soluble or water-insoluble. The drug is released from the matrix by diffusion or dissolution.
Coated Controlled-Release Tablets The sustained release tablets control the release of the drug using a polymer or polymer composition that encapsulates a core of the drug. The drug is gradually released in the core and then released to the external environment by diffusion or dissolution of the coating layer.
Porous Controlled-Release Tablets The sustained release tablets contain a drug matrix with an internal pore structure. The drug is released by diffusion or dissolution in the pores. It is designed to provide higher surface area and greater drug loading.
Osmotic Controlled-Release Tablets This sustained release tablet utilizes osmotic pressure differences to achieve a controlled release of the drug. The drug core is encapsulated in a semi-permeable membrane that allows water to enter and drive drug release. It provides a predictable and consistent rate of drug release.

Sustained Release Tablet Preparation Process

1. Formulation Development

Our experienced team works closely with you to develop customized formulations that meet your drug release requirements and therapeutic goals.

2. Excipient Selection

We carefully select excipients such as polymers, fillers, and binders to optimize drug release profiles and enhance tablet stability.

3. Granulation or Direct Compression

We use specialized equipment for granulation or direct compression of formulations to produce sustained release tablet granules or tablets.

4. Coating (if applicable)

For some sustained release tablet formulations, we can apply a coating layer to provide additional control over drug release and to protect the tablet.

5. Quality Control Testing

We conduct rigorous quality control testing to ensure that sustained release tablets meet requirements for dissolution, content uniformity, hardness, and stability.

Fig.2 Development of sustained-release dipyridamole formulations.Fig. 1 Development of sustained-release dipyridamole formulations containing organic acids as pH modifiers to modulate the microenvironmental pH for drug release in a hydrophilic polymer matrix. (Xi Z, et al. 2019)

Technology Used for Sustained Release Tablets

We utilize advanced technologies and state-of-the-art equipment to develop sustained release tablets. Our capabilities include:

Contact us today to discuss your project needs and explore how our services can help you successfully bring your sustained release tablets to market.


  1. Xi Z, et al. (2019). "Development and Evaluation of Dipyridamole Sustained Release Tablets Containing Micro-environmental pH Modifiers." Journal of Drug Delivery Science and Technology, 54, 101231.


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