Sustained release tablets are oral dosage forms designed to provide a gradual and sustained release of an active pharmaceutical ingredient (API) over an extended time. Unlike immediate-release tablets, which deliver the drug quickly into the bloodstream, sustained release tablets provide a controlled and sustained release of the drug, thereby maintaining therapeutic drug levels in the body for a longer period.

Protheragen-ING specializes in the development and manufacture of high-quality sustained release tablets. With our expertise in drug formulation and advanced manufacturing technologies, we offer a full range of services to take your sustained release tablet formulation from concept to market.

Benefits of Sustained Release Tablets

• Sustained release tablets ensure a slow and steady release of the drug, thus prolonging the duration of action and reducing the frequency of administration.
• By reducing the number of doses required per day, sustained release tablets improve patient convenience and compliance, resulting in better therapeutic outcomes.
• The controlled release of the drug helps minimize fluctuations in drug levels, reducing the incidence of side effects and maintaining a more consistent treatment outcome.
• Sustained release tablets optimize drug concentrations within the therapeutic window, maximizing efficacy and minimizing the risk of under or over-dosing.

Types of Sustained Release Tablets

Protheragen-ING can develop the following types of sustained release tablets:

Sustained Release Tablet Preparation Process

1. Formulation Development

Our experienced team works closely with you to develop customized formulations that meet your drug release requirements and therapeutic goals.

2. Excipient Selection

We carefully select excipients such as polymers, fillers, and binders to optimize drug release profiles and enhance tablet stability.

3. Granulation or Direct Compression

We use specialized equipment for granulation or direct compression of formulations to produce sustained release tablet granules or tablets.

4. Coating (if applicable)

For some sustained release tablet formulations, we can apply a coating layer to provide additional control over drug release and to protect the tablet.

5. Quality Control Testing

We conduct rigorous quality control testing to ensure that sustained release tablets meet requirements for dissolution, content uniformity, hardness, and stability.

Fig. 1 Development of sustained-release dipyridamole formulations containing organic acids as pH modifiers to modulate the microenvironmental pH for drug release in a hydrophilic polymer matrix. (Xi Z, et al. 2019)

Technology Used for Sustained Release Tablets

We utilize advanced technologies and state-of-the-art equipment to develop sustained release tablets. Our capabilities include:

• Hot melt extrusion
• Fluidized bed coating
• Tablet compression
• Drying in liquid technique
• Spray drying method
• Spray congealing
• Self-assembly method

Contact us today to discuss your project needs and explore how our services can help you successfully bring your sustained release tablets to market.