Hydrogel Drug Delivery System Development Services

Protheragen-ING specializes in the design and development of innovative drug delivery systems using hydrogels. With our expertise in the field, we offer comprehensive solutions to meet the diverse needs of the pharmaceutical and biomedical industries. Our hydrogel drug delivery system development services provide a comprehensive approach to the design and development of advanced drug delivery systems using hydrogels. We utilize the unique properties of hydrogels to achieve controlled release, targeted delivery, and enhanced therapeutic effects.

Hydrogels for Drug Delivery

Hydrogels are highly biocompatible, 3D cross-linked polymer networks capable of absorbing and retaining large amounts of water or biological fluids. Hydrogels can encapsulate drugs within their network structure, allowing for controlled release over a longer period, ensuring prolonged therapeutic effects while minimizing the frequency of administration.

Fig.1 Schematic representation of two mechanisms for drug release from a particle embedded in a hydrogel network.Fig. 1 Schematic representation of two mechanisms for drug release from a particle embedded in a hydrogel network. (Buwalda S.J, et al. 2017)

Protheragen-ING allows the hydrogel to be designed to respond to specific stimuli, such as pH, temperature, or enzymes, which can trigger release at the desired site in the body. This targeted drug delivery method improves the therapeutic index and reduces off-target effects. Our hydrogel drug delivery systems provide a versatile platform that can be customized to accommodate various drug types, including small molecules, proteins, peptides, and nucleic acids. The tunability of the hydrogel enables control of the drug release rate, resulting in sustained or targeted delivery profiles.

Comprehensive Hydrogel Drug Delivery Systems

Our hydrogel drug delivery system development services cover various solutions tailored to your specific needs. Whether you require an extended-release system, targeted delivery, or customized drug release kinetics, our team can design and optimize hydrogel formulations to meet your therapeutic goals. Our capabilities include, but are not limited to:

Fig.2 Drug-loaded contact lens hydrogel.Fig. 2 Drug-loaded contact lens hydrogel. (Raina N, et al. 2022)

Controlled Drug Release from Hydrogel Drug Delivery Systems

Our hydrogel drug delivery systems are precisely designed and optimized to achieve controlled drug release. We can achieve controlled drug release by controlling the degradation, swelling, and mechanical deformation of the hydrogel grid.

Our Hydrogel Preparation Methods

Physical Crosslinking Chemical Crosslinking
Hydrogen Bonding among Chains
Ionic Interaction
Crystallization
Hydrophobic Interactions
Crosslinking via Host-Guest Interactions
Click Chemistry Reaction
Schiff Base Approaches
Oxime Crosslink Method
Michael Type Addition Reaction
Enzymatic Crosslinking
Radiation Crosslinking
Hydrogel Crosslinking by Dynamic Covalent Chemistry

Contact us today to discuss your drug delivery needs and explore the possibilities of hydrogel-based solutions.

References

  1. Buwalda S.J, et al. (2017). "Hydrogels for Therapeutic Delivery: Current Developments and Future Directions." Biomacromolecules, 18(2), 316-330.
  2. Raina N, et al. (2022). "Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations." Pharmaceutics, 14(3), 574.

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