Dispersion Excipients


Dispersing excipients is a large class of essential and important medicinal excipients in several formulations, generally make the active pharmaceutical ingredients (API) into a molecular or ionic dispersion state (such as solution and colloidal solution) of the liquid dispersing medium known as solvents. When the excipients disperse the API into a particle state, such as emulsion, the dispersion excipients are known as surfactant that does not dissolve the API. These excipients are specifically designed to promote the dispersion of insoluble or poorly soluble API in various dosage forms.

Subtypes of Dispersion Excipients


Surfactants are essential dispersion excipients that facilitate the solubilization and dispersion of hydrophobic APIs in aqueous-based formulations. They lower the surface tension of the liquid medium, allowing for the formation of stable and uniform dispersions. Examples of surfactants commonly used in pharmaceutical formulations include polysorbates (e.g., Polysorbate 80), sodium lauryl sulfate, and cetyltrimethylammonium bromide.

Wetting Agents

Wetting agents are dispersion excipients that promote the rapid spreading and wetting of solid particles in a liquid medium. They reduce the interfacial tension between the particle surface and the liquid, facilitating uniform dispersion. Common wetting agents used in pharmaceutical formulations include polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and sorbitan esters.


Solvents, such as alcohols, glycols, and propylene glycol, are employed as dispersion excipients to enhance the solubility and dispersion of drugs. They act by dissolving or reducing the particle size of the APIs, leading to improved dissolution rates and bioavailability. Solvents are particularly useful for formulating oral solutions, suspensions, or soft gelatin capsules.

Dispersing Agents

Dispersing agents, also referred to as suspending agents, are excipients that prevent the aggregation or sedimentation of solid particles in liquid formulations. They ensure the uniform distribution and long-term stability of drug particles within the suspension. Examples of dispersing agents used in pharmaceutical formulations include carboxymethylcellulose sodium, xanthan gum, and sodium alginate.


Dispersion excipients are instrumental in formulating drug products with enhanced dissolution rates, improved bioavailability, and optimized therapeutic outcomes. From surfactants and wetting agents to solvents and dispersing agents, each subtype of dispersion excipient plays a crucial role in promoting uniformity and stability in drug formulations. By incorporating these excipients, pharmaceutical companies can effectively address formulation challenges associated with insoluble or poorly soluble APIs, ultimately leading to improved patient outcomes and medication efficacy. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0022 lecithin, from egg yolk (PL-100M) (for injection) 8057-53-2 View Details APIs
PIE-0023 lecithin, from egg yolk (PC-98T) (for injection) 8057-53-2 View Details APIs
PIE-0122 Polysorbate 80 9005-65-6 View Details APIs
PIE-0300 Chitosan 9012-76-4 View Details APIs


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