pH Modifier Excipients


The acceptable pH range for the body is 4–9. Body fluid levels that are too high can lead to acidosis or alkalosis, which can lead to physiological maladaptation and possibly put a person's life in peril. As a result, adding the proper acid, alkali, or buffer solution—also known as a pH adjuster—is typically required. pH adjuster can alter the pH level of a solution, either by donating or accepting hydrogen ions (H+). pH adjuster can 1. control the solubility of weak acid and weak alkali drugs, 2. make easy hydrolysis, easy to oxidize the drug in a stable pH state, 3. make the preparation pH in the physiological adaptability requirements, 4. adjust the pH value of the preparation, so that it can play the best effect.

Classification of pH Modifier Excipients

pH adjusters can be classified into three categories based on their mechanism of action:

  1. Buffers: Buffers are compounds that resist changes in pH when exposed to acidic or basic solutions. They work by reacting with excess H+ or OH- ions to maintain the desired pH level. Common buffers used in pharmaceutical formulations include sodium citrate, citric acid, and phosphate buffers.
  2. Acidic pH modifiers: These excipients lower the pH level of a solution by releasing H+ ions. Examples of acidic pH modifiers include acetic acid, tartaric acid, and hydrochloric acid.
  3. Basic pH modifiers: These excipients raise the pH level of a solution by consuming H+ ions. Examples of basic pH modifiers include sodium hydroxide, calcium carbonate, and triethanolamine.

pH adjusters play a vital role in ensuring the stability, bioavailability, and efficacy of pharmaceutical products. By modifying the pH level of a drug product, these excipients can enhance its solubility, stability, and therapeutic activity. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0008 (2-hydroxyethyl)piperazine-1-ethanesulfonic acid, (HEPES) (for injection) 7365-45-9 View Details APIs
PIE-0009 Tristearin hydrochloride (for injection) 1185-53-1 View Details APIs
PIE-0110 Glycine 56-40-6 View Details APIs
PIE-0116 Tartaric Acid 526-83-0 View Details APIs
PIE-0119 Citric acid 77-92-9 View Details APIs
PIE-0120 Sodium Citrate 68-04-2 View Details APIs
PIE-0125 Tannic Acid 1401-55-4 View Details APIs
PIE-0148 Disodium hydrogen phosphate 7558-79-4 View Details APIs
PIE-0149 Dipotassium hydrogen phosphate 7758-11-4 View Details APIs
PIE-0150 DL-tartaric acid 133-37-9 View Details APIs


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