Effervescent excipients are indispensable components in the formulation of pharmaceutical products that offer convenience, improved drug delivery, and enhanced patient experience. These excipients provide effervescence, a characteristic bubbling or fizzing effect, when in contact with water or other aqueous solutions.

Subtypes of Effervescent Excipients

Acid-Base Systems

The most common subtype of effervescent excipients involves acid-base systems. These systems typically consist of an acid (e.g., citric acid) and a carbonate or bicarbonate base (e.g., sodium bicarbonate). When the acid and base are brought into contact with water or saliva, a chemical reaction occurs, releasing carbon dioxide gas bubbles. This effervescence enhances dissolved drug dispersion, provides a pleasant sensory experience, and can aid in drug uptake in certain formulations. For example, citric acid, a widely used acid component in effervescent formulations, has strong acidic properties facilitate the release of carbon dioxide gas, resulting in effervescence and improved dissolution of drugs.

Salt-Acid Systems

Salt-acid effervescent systems involve the combination of a salt (e.g., tartaric acid) and an alkaline material (e.g., sodium gluconate). Upon contact with water, the acid reacts with the alkaline material, leading to effervescence. Salt-acid systems offer versatile options for controlled effervescence and can be tailored to specific formulation requirements. For example, sodium bicarbonate (also known as baking soda), a common base component in effervescent formulations, reacts with acids to generate carbon dioxide, thus creating the effervescent effect.

Oxygen-Releasing Systems

Oxygen-releasing effervescent systems are gaining prominence in pharmaceutical formulations. These systems can incorporate peroxides or materials that release oxygen upon interaction with water. This controlled-oxygen release can help improve drug stability, enhance wound healing, or create a favorable environment for certain therapeutic applications.


Effervescent excipients play a vital role in formulating pharmaceutical products that offer improved drug delivery, pleasant sensory experiences, and patient convenience. Acid-base, salt-acid, and oxygen-releasing effervescent systems are subtypes that enable effervescence and enhance drug solubility and stability. By harnessing the benefits of effervescent excipients, pharmaceutical companies can create innovative dosage forms that improve patient adherence, satisfaction, and therapeutic outcomes. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.



  • The products referred to herein are provided "as is" and Protheragen-ING makes no representation or guarantee of any kind regarding product specific information.
  • The use of the products covered in this article may not be permitted under the relevant pharmaceutical regulations in some jurisdictions. Therefore, please check the relevant regulations in your jurisdiction first to determine whether you have the right to use these products.
  • Protheragen-ING's basic premise for providing you with the products described herein is that you are solely responsible for ensuring your strict compliance with all applicable laws.

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