Dissolving Microneedle Development Services

Protheragen-ING specializes in the development and manufacturing of dissolving microneedles, a revolutionary technology that offers numerous benefits for drug delivery and cosmetic applications. With our expertise and cutting-edge facilities, we offer a comprehensive range of services to support your dissolving microneedle development needs. Whether you are a pharmaceutical company, a cosmetic brand, or a research organization, we will assist you in bringing your innovative ideas to life.


Dissolving microneedles are microscopic needles with a length of 25 to 2000 μm, a base diameter of 50 to 300 μm, and a tip diameter of 1 to 30 μm, prepared from various materials that can penetrate the stratum corneum. These needles are regularly arranged on a patch with an area of 1~2 cm2 and are a novel transdermal drug delivery system that can painlessly self-administer drugs.

Dissolving microneedles encapsulate the drug in a biodegradable polymer matrix and dissolve completely after insertion into the skin, leaving no biohazardous waste of sharp objects after use.

Fig.1 Dissolving microneedles.Fig. 1 Dissolving microneedles. (Sartawi Z, et al. 2022)

Our Services

We offer a full range of services to support your dissolving microneedle development program, including:

Our Dissolving Microneedle Preparation Method

The simple production method of Protheragen-ING is as follows: ① Prepare a polydimethylsiloxane (PDMS) mold of the appropriate size by laser drilling; ② A solution of the biodegradable polymer (containing API) of appropriate concentration is poured into the mold; ③ Vacuum to remove the excess solution; ④ Dry and demold to obtain microneedles.

Fig.2 The fabrication process of dissolving microneedle patches.Fig. 2 The fabrication process of dissolving microneedle patches. (Chen CH, et al. 2018)

After the microneedle is applied to the skin, an efficient absorption channel of active ingredients is formed on the skin surface by pressing, so that the active ingredients penetrate the epidermal layer of the skin, and the effective conductivity of the active ingredients reaches more than 90%.

Our commonly used matrix materials include carboxymethyl chitosan (CMC), polylactic acid (PLA), chondroitin sulfate, dextran, dextrin, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polylactic acid and other glycolic acid copolymers (PLGA), carboxymethylcellulose sodium (CMC-Na), and sericin protein.

Benefits of Our Dissolving Microneedles

Our Capabilities

Contact us today to learn more about how we can help you with your dissolving microneedle development journey.


  1. Sartawi Z, et al. (2022). "Dissolving Microneedles: Applications and Growing Therapeutic Potential." Journal of Controlled Release, 348, 186-205.
  2. Chen CH, et al. (2018). "Dissolving Microneedle Patches for Transdermal Insulin Delivery in Diabetic Mice: Potential for Clinical Applications." Materials, 11(9), 1625.


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