Drop Pill Base


Drops are spherical or similarly spherical formulations made by extracting, purifying, concentrating, and mixing the herbs with a suitable substrate by suitable methods of heating and melting, and then dropping them into an immiscible condensate. Materials in the drop pill formulations that aren't API are referred to as base. The drop pill base is a crucial component of the formulation. In addition to acting as drug carriers and determining the shape of the pill, bases can also be used to exert specific effects. For example, they can be used in conjunction with solid dispersion technology to increase the solubility of drugs and their rate of dissolution, enhancing their bioavailability and speed of action, or they can be made of slow-release formulations and some lipids to exert blocking effects.

Subtypes of Drop Pill Base

Hydrophobic Drop Pill Base: commonly used are stearic acid, glyceryl monostearate, hydrogenated vegetable oil, beeswax, etc.

Hydrophilic Drop Pill Base: commonly used are polyethylene glycol, soap, sodium stearate and glycerin gelatin, etc.

The majority of the drops produced in a practical application of drop production are made of water-soluble matrix, but the bases of the drops are frequently made of a combination of water-soluble matrix and non-water-soluble matrix. The two solubility properties of the matrix, with different polarity and dielectric constant, can be adjusted to each other and the nature of the drug similar polarity and dielectric constant, thereby increasing the solubility of the drug. Using a mixed base to manipulate the dissolution rate/period, such as polyethylene glycol 6000 and stearic acid.

Drop Pill Base Ideal Requirements

1. The base should be chemically inert, not react chemically with the primary drug, not interfere with the effectiveness and detection of the primary medication, and not have any negative effects on the human body.

2. The melting point of the drop-pill base shouldn't be too high; it can melt into a liquid when heated, condense into a solid when cooled suddenly, and stay solid at room temperature, maintaining the aforementioned physical condition after being mixed with the primary medicine.

3. The dispersing ability and cohesive force of the base should be fully considered. Typically, a substrate with a high surface tension is easier to mold, and a substrate that cannot be molded is one whose cohesion is insufficient to overcome the adhesion between the droplets and the condensate following the production of molten droplets.

4. Control the dosage ratio of the medicine and the matrix to guarantee that the dosage form is stable and effective by lowering the dosage of the matrix.

Examples of Drop Pill Bases

PEG 6000
Sodium Stearate
Poloxamer 188
Polyoxyethylene (40) Stearate


Drop Pill Base can be employed to produce particular effects in addition to carrying drugs and forming the structure of the drop pills. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0104 Polyethylene glycol, PEG, 400 25322-68-2 View Details APIs


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