Transferosomes Development Services

Transferosomes are specialized lipid vesicles designed to enhance the delivery of active pharmaceutical ingredients (APIs) across biological barriers, such as the skin or mucous membranes.

Protheragen-ING specializes in providing cutting-edge transferosome development services to meet the unique needs of our clients. Our team of highly skilled scientists and researchers is dedicated to advancing the field of drug delivery through the development and optimization of transferosome-based formulations.


Transferosomes were developed in 1991 as a new class of novel carriers that can be defined as superdeformable, stress-responsive, complex vesicles with an aqueous core surrounded by a complex lipid bilayer. These artificial vesicles consist of a natural amphiphilic lipid (e.g., phosphatidylcholine, dipalmitoylphosphatidylcholine) supplemented with a bilayer softener, a biocompatible surfactant.

Fig.1 The mechanism of action of transfersomes.Fig. 1 The mechanism of action of transfersomes. (Opatha SAT, et al. 2020)

Advantages of transferosomes:

Our Transferosomes Development Services

Fig.2 Transferosomes structure are vesicular carrier systems that enclosed by a lipid bilayer with DNA strands conjugated molecules 3d rendering.

We collaborate with clients to develop transferosome formulations tailored to their specific drug candidates. We utilize state-of-the-art techniques and cutting-edge technology to optimize the encapsulation efficiency, stability, and release kinetics of APIs within transferosomes.

We provide comprehensive process optimization services to enhance the scalability and reproducibility of transferosome manufacturing. Our experts utilize Quality by Design (QbD) principles and statistical tools to identify critical process parameters and optimize formulation techniques, ensuring consistent and high-quality transferosome production.

Our advanced analytical techniques enable us to assess parameters such as size distribution, zeta potential, morphology, drug entrapment efficiency, and drug release profiles. This information helps in understanding the behavior and performance of transferosome formulations.

We conduct comprehensive stability studies to evaluate the long-term stability and shelf-life of transferosome formulations under various storage conditions. Our team employs accelerated stability testing protocols, including stress testing and forced degradation studies, to assess the robustness and integrity of the developed transferosome formulations.

Our scientists conduct permeation studies, skin penetration assays, and pharmacokinetic analysis to determine the bioavailability and tissue distribution of APIs delivered through transferosomes.

We provide regulatory support and guidance throughout the transferosome development process. Our team can assist in preparing the necessary documentation, including regulatory submissions and data packages, to facilitate the approval and commercialization of transferosome-based drug products.

Our Transferosomes Preparation Methods

If you are interested in our transferosomes development services or have any inquiries, please don't hesitate to contact us. Our team of experts is ready to assist you in achieving your drug delivery goals through innovative transferosome development.


  1. Opatha SAT, et al. (2020). "Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery." Pharmaceutics, 12(9), 855.


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