Capsule Excipients


Capsule filler excipients are inactive ingredients used in combination with active pharmaceutical ingredients (APIs) to create pharmaceutical capsules. These excipients serve multiple functions, including ensuring the proper filling, disintegration, release, and stability of the drug within the capsule. Together with capsule shell, they play a significant role in determining the release profile, bioavailability, and overall performance of API.

Subtypes of Capsule Excipients


Diluents are bulking agents used to provide volume and achieve the desired weight of the capsule. These excipients enhance the manufacturing process by ensuring uniformity of the fill and proper capsule closure. Common diluents include microcrystalline cellulose, lactose, mannitol, and starches.


Binders are excipients that promote cohesion and facilitate the formation of a solid dosage form. They help in maintaining tablet integrity and preventing the drug from falling apart or crumbling within the capsule.


Lubricants are essential excipients that minimize friction between the granules or particles of the drug formulation, allowing for smoother capsule filling and ejection from the manufacturing equipment. Popular lubricants include magnesium stearate, stearic acid, and sodium stearyl fumarate.


Disintegrants are added to capsule formulations to aid the rapid break-up or disintegration of the capsule shell upon ingestion, facilitating drug release and absorption. Commonly used disintegrants include croscarmellose sodium, crospovidone, and sodium starch glycolate.


Glidants improve the flow properties of the powder blend, ensuring uniform mixing and preventing segregation during capsule filling. These excipients promote efficient capsule filling and minimize content variations. Examples of glidants include colloidal silicon dioxide and talc.


Capsule excipients are integral components in pharmaceutical capsule formulations, playing a vital role in achieving optimal drug delivery, stability, and patient acceptance. By selecting the right excipients, pharmaceutical companies can enhance the performance, bioavailability, and therapeutic outcomes of their products. Partnering with Protheragen-ING, a reliable supplier, offers a comprehensive range of capsule excipients ensures access to high-quality ingredients that meet regulatory requirements and contribute to the development of capsules. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0028 Microcrystalline Cellulose 9004-34-6 View Details APIs
PIE-0047 Maize Starch 65996-63-6 View Details
PIE-0299 Polylactic acid 26100-51-6 View Details APIs


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