Granule Development Services


Granules are an oral solid dosage form that is small, discrete particles or aggregates of particles containing one or more active pharmaceutical ingredients (APIs) and other excipients. Granules offer several advantages in drug formulation. They can improve the flow characteristics of the drug, enhance compressibility, and provide uniform distribution of the API and excipients. Granules are commonly used as intermediates in manufacturing various solid dosage forms such as tablets and capsules.

Protheragen-ING is an expert in pharmaceutical formulation development and dosage form optimization. We can provide you with a one-stop service and can design granule formulations to meet your granule needs based on the characteristics of the API and the development goals of the customer.

Protheragen-ING's Granule Development Services

Production Methods for Granule Formulations

Protheragen-ING uses a variety of technologies to produce granules. The choice of method depends on the nature of the drug and the desired characteristics of the final dosage form.

It involves mixing the drug and excipient and pressing them directly into granules without the need for a wet or dry granulation step.

Direct compression is advantageous when the API and excipient have good flowability and compressibility.

It involves the use of pressure or compaction rollers to press the drug and excipients into blocks or ribbons, which are then ground or sieved to obtain granules. It is a technique used when the drug or excipient is moisture or heat-sensitive.

This involves mixing APIs and excipients with a liquid binder to form wet agglomerates, which are then dried and sieved to obtain granules of the desired size.

Advantages include improved flowability, enhanced compressibility and better content uniformity. Suitable for drugs that are heat sensitive or have poor flowability.

Schematic presentation of the wet granulation process.Fig. 1 Schematic presentation of the wet granulation process. (Kumar A, et al. 2014)

The Cases for Granules

Several drugs are commonly formulated into granules for oral administration. Here are some examples:

Contact us today to learn more about our granule development services and how we can support your pharmaceutical product development needs.


  1. Kumar A, et al. (2014). "Experimental Investigation of Granule Size and Shape Dynamics in Twin-screw Granulation." International Journal of Pharmaceutics, 475(1-2), 485-495.


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