Ointment Base


Ointment is a topical medication that is semi-solid and consists of extracts, finely ground tablets, and an appropriate base. Most of them provide lubrication, protection, and local therapeutic effects. A few, especially those used to treat chronic skin conditions, can also generate systemic therapeutic effects when absorbed through the skin. The development and effectiveness of an ointment depend heavily on the matrix. The composition of the ointment matrix has a significant impact on the efficacy, rheological characteristics, appearance, and other aspects of the ointment as well as the release and absorption of the medication.

The selection of base materials depends on the 1) local protecting, moisturizing, and therapeutic effects; 2) the systemic effects that from skin absorption. In the first scenario, a poorly penetrating matrix is advised, however in the second scenario, it's crucial to pick a mechanism that is simple to release and penetrate.

Subtypes of Ointment Base

Anhydrous Ointment Base: Anhydrous Ointment Bases are oil-based formulations that do not contain water. They are composed of a blend of lipophilic components, such as oils, waxes, and fatty acids. Anhydrous Ointment Bases offer advantages such as occlusivity, prolonged drug release, and enhanced drug penetration. They are commonly used for hydrophobic APIs and in formulations requiring a barrier function.

Water-in-Oil (W/O) Ointment Base: Water-in-Oil Ointment Bases consist of water droplets dispersed in an oil phase. They provide a more emollient and occlusive effect compared to anhydrous bases. W/O Ointment Bases are suitable for hydrophilic APIs and offer advantages such as enhanced hydration, improved drug solubility, and prolonged moisturization. They are commonly used in formulations for dry and sensitive skin.

Oil-in-Water (O/W) Ointment Base: Oil-in-Water Ointment Bases consist of oil droplets dispersed in a continuous water phase. They provide a lighter and less greasy texture compared to anhydrous bases. O/W Ointment Bases are suitable for hydrophobic APIs and offer advantages such as improved spreadability, easy wash-off, and cooling effect upon application. They are commonly used in formulations for oily or acne-prone skin.

Basic Requirements on Ointment Base

1. Easy to spread, proper consistency, and lubricating yet non-irritating

2. Natural stable, doesn't react with API

3. Capable of absorbing wound secretions

4. Has good medication release qualities and does not obstruct the skin's natural ability to operate

5. Simple to remove and leaves no stains on clothing

Applications of Ointment Base


Ointment Bases are widely used in the formulation of medicinal ointments, including topical antibiotics, antifungals, corticosteroids, and wound healing products. They provide a stable and occlusive environment for the active ingredients, allowing for controlled release and prolonged contact with the skin.

Cosmeceutical Products

Ointment Bases are utilized in the formulation of cosmeceutical products, including anti-aging creams, skin brightening formulations, and specialty skincare products. They facilitate the delivery of cosmetic actives, enhancing their efficacy and ensuring their proper absorption into the skin.


Ointment Base serves as a versatile vehicle for topical formulations, providing a stable and effective platform for the delivery of active pharmaceutical ingredients and cosmetic actives. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0066 Aluminum Monostearate 7047-84-9 View Details APIs
PIE-0071 Dimethicone, viscosity 10 9006-65-9 View Details APIs
PIE-0072 Dimethicone, viscosity 50 9006-65-9 View Details APIs
PIE-0073 Dimethicone, viscosity 100 9006-65-9 View Details APIs
PIE-0074 Dimethicone, viscosity 1000 9006-65-9 View Details APIs
PIE-0075 Dimethicone, viscosity 2000 9006-65-9 View Details APIs
PIE-0076 Dimethicone, viscosity 10000 9006-65-9 View Details APIs
PIE-0089 Cyclomethicone 69430-24-6 View Details
PIE-0104 Polyethylene glycol, PEG, 400 25322-68-2 View Details APIs
PIE-0105 Polyethylene glycol, PEG, 4000 25322-68-2 View Details APIs
PIE-0106 Polyethylene glycol, PEG, 6000 25322-68-3 View Details APIs
PIE-0277 PEG 600 25322-68-3 View Details APIs
PIE-0278 PEG 1000 25322-68-3 View Details APIs


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