Pharmacosomes are amphiphilic lipid vesicle systems containing phospholipid complexes with the potential to enhance the bioavailability of poorly water-soluble and poorly lipophilic drugs. Protheragen-ING is a leading provider of integrated development services for pharmacosomes, delivering innovative solutions to pharmaceutical companies worldwide. Our team of experts is dedicated to assisting you at every stage of pharmacosomes development, from concept to commercialization.

Introduction

Pharmacosomes can be defined as neutral molecules with optimal ratios of polyphenols to phospholipids in both positively and negatively charged, hydrophilic and lipophilic properties as well as complex forms. Drugs are present as dispersions in these lipid-based drug delivery systems, bound by electron pair sharing and electrostatic forces or by forming hydrogen bonds with lipids.

Pharmacosomes are the system of vesicles in which the drug binds to the carrier. These lipid-conjugated vesicles can exist as colloids, nanosized micelles, vesicles, or can exist as hexagonal assemblies with functional hydrogen atoms based on the structure of the complex.

Our Services

Pharmacodynamic Formulation Development

We utilize cutting-edge technologies and formulation strategies to improve drug solubility, stability and bioavailability, ultimately maximizing therapeutic efficacy.

Preclinical Evaluation

Our preclinical evaluation services include rigorous testing and characterization of pharmacophores to assess their safety, efficacy and pharmacokinetic properties. We utilize state-of-the-art analytical techniques and animal models for in vitro and in vivo studies to provide valuable insights into the performance of your pharmacological formulations.

Analytical Method Development

We design and optimize methods for quantifying drug encapsulation efficiency, particle size distribution, drug release kinetics, and other key parameters to enable comprehensive characterization of your pharmacological formulations.

Stability Studies

We conduct accelerated and long-term stability studies under a variety of storage conditions to evaluate the physical and chemical stability of your pharmacological formulations over time.

Scale-up and Manufacturing Support

Our team assists with technology transfer, process optimization, and quality control to ensure a seamless transition from development to commercial production.

Regulatory Support

We provide assistance in preparing regulatory submissions, addressing inquiries from regulatory agencies, and ensuring compliance with relevant regulations.

Fig. 1 Doxifluridine-based pharmacosomes for hepatocellular carcinoma (HCC) treatment. (Xue F, et al. 2021)

Materials for Pharmacosomes

The following components may be utilized for the preparation of pharmacosomes.

Preparation of Pharmacosomes

To form pharmacosomes, drug-lipid complexes are required. The salt form of the drug is converted to an acidic form to expose functional hydrogen atoms and form complexes. The aqueous solution of the drug was acidified, extracted with chloroform, and then recrystallized. The equimolar phospholipid concentration was then dissolved in an organic solvent and then evaporated under a vacuum at a certain temperature. The complex is collected as a dry residue after being placed in a desiccator overnight.

Generally, there are two methods for the preparation of the pharmacophore.

• Solvent Evaporation Technique
• Ether-Injection Technique

Contact us today to learn more about our services and how we can assist you in advancing your pharmacosome-based drug delivery systems.