Plasticizer Excipients

Introduction

Plasticizer excipients are essential additives used to increase the flexibility, pliability, and processability of various pharmaceutical formulations. Plasticizers are generally high boiling point liquids and some low molecular weight polymers that can be uniformly dispersed in film forming materials. Plasticizers interact with the polymer of the film-forming material to enhance the fluidity of the polymer chains and improve the physical and mechanical properties of the film. Film-coated tablets, enteric-coated tablets, film formulations, film-coated formulations, capsules, transdermal formulations and other dosage forms generally require the addition of plasticizers.

Subtypes of Plasticizer Excipients

Phthalate Plasticizers

Phthalate plasticizers, such as diethyl phthalate (DEP) and dibutyl phthalate (DBP), have been traditionally used in the pharmaceutical industry. They provide excellent flexibility and are commonly employed in solid dosage forms, including tablets and capsules.

Citrate Plasticizers

Citrate plasticizers, such as triethyl citrate (TEC) and acetyl triethyl citrate (ATEC), are widely used as alternatives to phthalate plasticizers. They offer excellent plasticizing properties and are suitable for various dosage forms, including films, coatings, and enteric formulations.

Glycol Plasticizers

Glycol plasticizers, such as polyethylene glycol (PEG), provide outstanding mechanical properties to dosage forms. They are commonly used in liquid and semi-solid formulations, including ointments, creams, and oral suspensions.

Acetate Plasticizers

Acetate plasticizers, such as triacetin (glycerol triacetate), exhibit excellent plasticizing properties and are frequently used in oral films, transdermal patches, and gelatin capsules.

Applications

Enteric Coatings
Transdermal Patches
Oral Films
Topical Formulations

To choose plasticizer

Ideal plasticizers should meet the following requirements:

1. Colorless and odorless
2. Non-volatile
3. Thermally stable
4. Waterproof
5. Chemically stable
6. Non-migrating in the film
7. No toxic side effects

Conclusion

Pharmaceutical plasticizer excipients play a vital role in enhancing the flexibility, processability, and functionality of various pharmaceutical dosage forms. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0031 N-Vinyl-2-pyrrolidone, PVPP 9003-39-8 View Details APIs
PIE-0034 Wheat Starch 9005-25-8 View Details
PIE-0037 Sodium carboxymethyl cellulose 9004-32-4 View Details APIs
PIE-0039 High-Substituted Hydroxypropyl cellulose 9004-64-2 View Details APIs
PIE-0048 Dextrin 9004-53-9 View Details APIs
PIE-0067 Medium-chain Triglycerides 73398-61-5 View Details APIs
PIE-0090 Triethyl Citrate 77-93-0 View Details APIs
PIE-0091 Diethyl Phthalate 84-66-2 View Details APIs
PIE-0096 Glyceryl Monostearate 123-94-4 View Details APIs
PIE-0097 Glyceryl Mono-and Distearate 1323-83-7 View Details APIs
PIE-0098 Glyceryl Monolinoleate 26545-74-4 View Details APIs
PIE-0101 Glyceryl Triacetate 102-76-1 View Details APIs
PIE-0104 Polyethylene glycol, PEG, 400 25322-68-2 View Details APIs
PIE-0122 Polysorbate 80 9005-65-6 View Details APIs
PIE-0124 D-Mannitol 69-65-8 View Details APIs
Inquiry

Note:

  • The products referred to herein are provided "as is" and Protheragen-ING makes no representation or guarantee of any kind regarding product specific information.
  • The use of the products covered in this article may not be permitted under the relevant pharmaceutical regulations in some jurisdictions. Therefore, please check the relevant regulations in your jurisdiction first to determine whether you have the right to use these products.
  • Protheragen-ING's basic premise for providing you with the products described herein is that you are solely responsible for ensuring your strict compliance with all applicable laws.
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