Nucleic Acid Drug Raw Materials

Nucleic acid drugs play an important role in the treatment of genetic diseases, tumors, viral infections, metabolic diseases and other diseases. Protheragen-ING provides high-quality and extensive nucleic acid raw materials for the pharmaceutical industry.

Nucleic Acid Drug Raw Materials

Extensive Product Categories

Our core raw materials for nucleic acid drugs fall into the following categories:

Nucleotides

Nucleotides are the raw materials for the synthesis of mRNA vaccines and nucleic acid drugs. Our nucleotide series products cover NTP, pseudouridine, and modified nucleotides.

NTP

Protheragen-ING's NTP family of products has been extensively tested and validated to be suitable for a variety of molecular biology applications. We offer a variety of specifications for customers to choose from, and all formulations are designed for ease of use and flexibility.

Cat Product Name Purity Specification Price
PIPB-0041 ATP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0042 UTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0043 GTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0044 CTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0045 NTP kits (100 mM) ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0046 NTP MIX25 mM sodium solution each ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0047 ATP, 10 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0048 UTP, 10 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0049 GTP, 10 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0050 CTP, 10 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0051 NTP kits (10 mM) ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0052 NTP MIX 2.5 mM sodium solution each ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0053 ATP, 100 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0054 UTP, 100 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0055 GTP, 100 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0056 CTP, 100 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0057 NTP kits (100 mM Tris Solution) ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0058 ATP, 200 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0059 UTP, 200 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0060 GTP, 200 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0061 CTP, 200 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY

Modified Nucleotide

Modified nucleotides are nucleotide analogs that contain one or more chemically modified groups such as methyl groups. Chemically modified nucleotides can reduce immunogenicity without affecting their translational properties, greatly broadening the field of practical applications of nucleotides.

Cat Product Name Purity Specification Price
PIPB-0062 5-Me-CTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0063 5-OMe-UTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0064 3'-OMe-GTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0065 3'-NH2-GTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0066 2-NH2-ATP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0067 2-F-ATP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY
PIPB-0068 5-Me-UTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL INQUIRY

Pseudouridine

Pseudouridine is the most abundant modification in intracellular RNA. The technique of replacing uridine with pseudouridine can not only greatly reduce the immunogenicity of mRNA, but also reduce the immunogenicity of RNA with an increasing proportion of pseudouridine. The complete replacement of uridine by N1-methylpseudouridine can reduce the immunogenicity of mRNA and enhance the ability of protein expression in mRNA more than the complete replacement of uridine by pseudouridine.

Cat Product Name Purity Specification Cas Details Chemical Structure
PIPB-0069 Pseudouridine ≥99.0% g, kg 1445-07-4 View Details APIs
PIPB-0070 N1-Me-Pseudouridine ≥99.0% g, kg 13860-38-3 View Details APIs
PIPB-0071 Pseudo-UTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL 1175-34-4 View Details APIs
PIPB-0072 Pseudo-UTP, 100 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL View Details
PIPB-0073 N1-Me-pUTP, 100 mM Sodium Solution ≥99.0% 1mL, 10mL, 100mL 1428903-59-6 View Details APIs
PIPB-0074 N1-Me-pUTP, 100 mM Tris Solution ≥99.0% 1mL, 10mL, 100mL View Details

LNP Raw Materials

The single-stranded structure of mRNA itself is unstable and carries a negative charge, which is difficult to cross the cell membrane with a negative charge. Lipid nanoparticles (LNP) can effectively deliver mRNA to achieve intracellular expression of mRNA.

Cat Product Name Purity Specification Cas Details Chemical Structure
PIPB-0075 ALC-0315 ≥98.0% 1 g, 10 g, 100 g 2036272-55-4 View Details APIs
PIPB-0076 SM-102 ≥98.0% 1 g, 10 g, 100 g 2089251-47-6 View Details APIs
PIPB-0077 DLin-MC3-DMA ≥98.0% 1 g, 10 g, 100 g 1224606-06-7 View Details APIs
PIPB-0078 DOTAP ≥98.0% 1 g, 10 g, 100 g 132172-61-3 View Details APIs
PIPB-0079 DSPA ≥98.0% 10 g, 100 g, kg 108321-18-2 View Details APIs
PIPB-0080 DOPE ≥98.0% 10 g, 100 g, kg 4004-05-1 View Details APIs
PIPB-0081 DSPC ≥98.0% 10 g, 100 g, kg 816-94-4 View Details APIs
PIPB-0082 DOPC ≥98.0% 10 g, 100 g, kg 4235-94-4 View Details APIs
PIPB-0083 ALC-0159 ≥98.0% 10 g, 100 g, kg 1849616-42-7 View Details APIs
PIPB-0084 DMG-PEG 2000 ≥98.0% 10 g, 100 g, kg 160743-62-4 View Details APIs
PIPB-0085 DSPE-PEG ≥98.0% 10 g, 100 g, kg 474922-77-5 View Details APIs

GalNAc

Delivery mode and efficiency are the key to whether small nucleic acid drugs can enter cells and play a role. Galnac-nucleic acid is a monoconjugate of carbohydrate compounds and nucleic acid, which has a high affinity for ASGPR. After GaINAc binds to ASGPR on the surface of liver parenchymal cells, it enters the cells to form endosomes through cellular endocytosis, delivering a sufficient amount of siRNA into the cells.

Cat Product Name Purity Cas Details Chemical Structure
PIPB-0086 GalNac-L96 ≥98.0% 1159408-61-3 View Details APIs
PIPB-0087 GalNac-L96 analog ≥98.0% 1159408-72-6 View Details APIs
PIPB-0088 Tri-GalNAc(OAc)3 TFA ≥98.0% 1159408-65-7 View Details APIs

Cap Analogs

The 5'-end cap structure of mRNA is closely related to its immunogenicity and stability. The "capping" of mRNA structures plays a crucial role in a variety of cellular processes such as translation initiation, splicing, and intracellular transport. Modifying mRNA with cap analogs can improve translation and transfection efficiency.

Cat Product Name Purity Specification Price
PIPB-0089 CAP GAG ≥98.0% 100μL,1mL,10mL,100mL INQUIRY
PIPB-0090 CAP GAG (3' OMe) ≥98.0% 100μL,1mL,10mL,100mL INQUIRY
PIPB-0091 CAP GGG ≥98.0% 100μL,1mL,10mL,100mL INQUIRY
PIPB-0092 CAP GGG (3' OMe) ≥98.0% 100μL,1mL,10mL,100mL INQUIRY
PIPB-0093 CAP GAG (m6A) ≥98.0% 100μL,1mL,10mL,100mL INQUIRY
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