Carrier Excipients

Introduction

Carrier excipients are inert substances that are added to pharmaceutical formulations to improve drug delivery and performance. These excipients do not possess therapeutic activity themselves but enhance the properties of the active drug. They can be categorized based on their specific functions and characteristics, which contribute to the overall efficacy and stability of the drug formulation.

Basic Requirements on Carrier Excipients

1. Consistent physical and chemical characteristics

2. Appropriate release rate

3. Non-irritating and non-toxic

4. May be combined with the drug, and content measurement and the pharmacological impact of the drug are unaffected.

5. Have a certain amount of strength and plasticity, which allows them to completely encase the capsule's core or to integrate the medicine and additives more fully into the skeleton.

6. Possess the necessary permeability, hydrophilicity, solubility, and viscosity, among other qualities.

7. Biocompatibility and biodegradability are additional requirements for the injectable carrier material.

Subtypes of Carrier Excipients

Natural polymer materials: commonly used gelatin, alginate, proteins, etc., this type of material is non-toxic, good film-forming and stable.

Semi-synthetic polymer materials: the most commonly used is cellulose derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, etc., which is characterized by low toxicity, high viscosity, and increased solubility after salt formation.

Synthetic polymer materials: commonly used are polyvinyl alcohol, polyvinyl ketone, polycarbonate, etc., which are characterized by good film-forming properties and chemical stability.

How to Choose Carrier Excipients

  1. Based on the purpose of microcapsules: the capsule material basically determines the nature and role of the microcapsules, so the selection of the first to ascertain the purpose of microcapsules for improving the stability of the drug, or masking the bad odor, or to make the liquid drug solid state, or for controlled release and prolonged effect, or to prevent contraindications, and so on. On this basis, and then screen the appropriate capsule material to achieve the corresponding purpose, that is, what kind of capsule material should be used to meet the special requirements of medical treatment and formulation for the purpose.
  2. Based on the nature of the drug, the physicochemical properties of the carrier material and the requirements of the formulations: when choosing the carrier material, it should be considered from the physicochemical point of view of its annual, permeability, hygroscopicity, solubility, stability and the nature of the drug, and at the same time, combined with the requirements of the clinic and the preparation.

Carrier excipients are essential components of pharmaceutical formulations, enhancing drug delivery, stability, and performance. Working with Protheragen-ING, a professional supplier, supports the creation of stable and effective pharmaceutical products by ensuring the availability of high-quality excipients. Please get in touch with us by phone or email if you have any excipient needs, and we'll get back to you within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0017 Tricaprylin 538-23-8 View Details APIs
PIE-0022 lecithin, from egg yolk (PL-100M) (for injection) 8057-53-2 View Details APIs
PIE-0023 lecithin, from egg yolk (PC-98T) (for injection) 8057-53-2 View Details APIs
PIE-0039 High-Substituted Hydroxypropyl cellulose 9004-64-2 View Details APIs
PIE-0045 Beta-cyclodextrin 7585-39-9 View Details APIs
PIE-0049 Hypromellose Acetate Succinate 71138-97-1 View Details APIs
PIE-0050 HPMCP 9050-31-1 View Details APIs
PIE-0054 Sucrose core / View Details
PIE-0085 Pentetic Acid 67-43-6 View Details APIs
PIE-0355 Bottle/Lid View Details
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