Chelating Agents


Chelating agents are compounds designed to bind and complex metal ions, effectively sequestering them and reducing their catalytic potential. By chelating metal ions, these agents help prevent oxidation, hydrolysis, and other degradation reactions that can compromise the stability and efficacy of pharmaceutical formulations. By employing chelating agents, pharmaceutical companies can enhance the shelf life and overall quality of their medications.

Subtypes of Pharmaceutical Chelating Agents

Amino Acids

Certain amino acids, such as histidine and cysteine, possess chelating properties due to the presence of functional groups capable of forming strong coordination bonds with metal ions. These amino acids are used both as chelating agents and as excipients in pharmaceutical formulations to stabilize metal ions and mitigate their deleterious effects.

EDTA (Ethylene Diamine Tetraacetic Acid) and Its Derivatives

EDTA, a highly versatile chelating agent, forms stable complexes with metal ions, preventing their participation in degradation reactions. Modified derivatives of EDTA, such as disodium EDTA and calcium disodium EDTA, are commonly employed in pharmaceutical formulations to stabilize metal ions, enhance product stability, and extend shelf life.

DTPA (Diethylenetriaminepentaacetic Acid) and Its Derivatives

DTPA is another widely used chelating agent that forms stable complexes with metal ions. Its derivatives, such as calcium trisodium pentetate and zine-dtpa, are utilized in pharmaceutical formulations to chelate specific metal ions, such as calcium and zinc. These agents help prevent metal ion-catalyzed degradation reactions, thus maintaining the integrity of the medication.

Dimercaprol (British Anti-Lewisite or BAL)

Dimercaprol is a chelating agent employed for the treatment of heavy metal poisoning, specifically arsenic, lead, and mercury. It forms complexes with these toxic metal ions, facilitating their excretion from the body. Dimercaprol is primarily used in hospital settings as an antidote and is crucial in relieving the symptoms of heavy metal toxicity.


Pharmaceutical chelating agents play a crucial role in stabilizing drug formulations and preserving their efficacy. By effectively sequestering metal ions, these agents prevent degradation reactions and enhance the shelf life of medications. Exploring different subtypes of chelating agents, such as amino acids, EDTA derivatives, and DTPA derivatives, opens up possibilities for tailored solutions. Partnering with Protheragen-ING, a reputable supplier, ensures the availability of high-quality excipients and supports the development of stable and efficacious pharmaceutical products. If you have any excipient requirements, please contact us by phone or email, and we will respond within 2-4 working days.

Cat Product Name Cas Details Chemical Structure
PIE-0085 Pentetic Acid 67-43-6 View Details APIs
PIE-0116 Tartaric Acid 526-83-0 View Details APIs
PIE-0125 Tannic Acid 1401-55-4 View Details APIs
PIE-0148 Disodium hydrogen phosphate 7558-79-4 View Details APIs
PIE-0150 DL-tartaric acid 133-37-9 View Details APIs
PIE-0151 Disodium edetate (EDTA) 6381-92-6 View Details APIs
PIE-0279 DOTA 60239-18-1 View Details APIs
PIE-0307 Calcium Sodium Edetate 62-33-9 View Details APIs
PIE-0392 Disodium Edetate 139-33-3 View Details APIs


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